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Panama Canal cruise
Panama Canal cruise ship in lock

San Diego Cruise Guide > Cruise Destinations > Panama Canal

Panama Canal Cruises from San Diego

Four cruise lines offer cruises through the Panama Canal from San Diego. They are all one-way trips that end in Florida. All go fully through the canal, and they visit lots of resort ports along the way. See the full schedule of departures below.

This time-lapse video shows a full transit of a cruise ship through the Panama Canal in just 5 minutes. The actual trip was more than 10 hours.

The Panama Canal is 100 years old, and is one of the engineering marvels of the world. A voyage through the canal is a real "must do" adventure. See an interesting 100 years of the Panama Canal in 10 photos gallery by PBS.

Panama Canal cruise itinerary
Panama Canal cruise port of call

Panama Canal Cruises from San Diego 2017

October 5, 2017: 16-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, and Aruba.

October 27, 2017: 14-night Panama Canal cruise on Disney Cruises. One-way from San Diego to Port Canaveral (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), the Panama Canal, Cartagena (Colombia), and Cozumel (Mexico). This is a "Halloween on the High Seas" cruise.

November 8, 2017: 15-night Panama Canal cruise on Celebrity Cruises. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama), and Cartagena (Colombia).

December 8, 2017: 14-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, and Cartagena (Colombia).

December 20, 2017: 15-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia), and Half Moon Cay (Bahamas).

Panama Canal Cruises from San Diego 2018

January 20, 2018: 15-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).

February 20, 2018: 17-night Panama Canal cruise on Azamara Cruises. One-way from San Diego to Miami (Florida). Visit Cabo San Lucas (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), San Juan Del Sur (Nicaragua), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).

March 4, 2018: 15-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).

March 9, 2018: 15-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).

April 17, 2018: 15-night Panama Canal cruise on Celebrity Cruises. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama) and Cartagena (Colombia).

April 22, 2018: 20-day Panama Canal cruise on Holland America Line. One-way from San Diego to Boston (Massachusetts). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia), Half Moon Cay (Bahamas), Fort Lauderdale (Florida) and Charleston (South Carolina).

September 9, 2018: 15-night Panama Canal cruise on Celebrity Cruises. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama) and Cartagena (Colombia).

October 9, 2018: 15-night Panama Canal cruise on Celebrity Cruises. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama) and Cartagena (Colombia).

October 19, 2018: 14-night Panama Canal cruise on Disney Cruises. One-way from San Diego to Galveston (Texas). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), the Panama Canal, Cartagena (Colombia), Grand Cayman (Cayman Islands) and Cozumel (Mexico).

For more optons, see Panama Canal cruises from Los Angeles. They are similar to the ones out of SD. Also available are Panama Canal cruises from Fort Lauderdale, which often sail to San Diego. They are the reverse of the ones listed here.

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