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Panama Canal cruise
Panama Canal cruise ship in lock

San Diego Cruise Guide > Cruise Destinations > Panama Canal

Panama Canal Cruises from San Diego

Five cruise lines offer cruises through the Panama Canal from San Diego. They are all one-way trips that end in Florida. All go fully through the canal, and they visit lots of resort ports along the way. See the full schedule of departures below.

This time-lapse video shows a full transit of a cruise ship through the Panama Canal in just 5 minutes. The actual trip was more than 10 hours.

The Panama Canal is 100 years old, and is one of the engineering marvels of the world. A voyage through the canal is a real "must do" adventure. See an interesting 100 years of the Panama Canal in 10 photos gallery by PBS.

Panama Canal cruise itinerary
Panama Canal cruise port of call

2018

September 9, 2018: 15-night Panama Canal cruise on Celebrity Cruises. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama) and Cartagena (Colombia).

October 9, 2018: 15-night Panama Canal cruise on Celebrity Cruises. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama) and Cartagena (Colombia).

October 19, 2018: 14-night Panama Canal cruise on Disney Cruises. One-way from San Diego to Galveston (Texas). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), the Panama Canal, Cartagena (Colombia), Grand Cayman (Cayman Islands) and Cozumel (Mexico).

October 21, 2018: 14-day Panama Canal cruise on Norwegian Cruise Line. One-way from San Diego to Tampa (Florida). Visit Cabo San Lucas (Mexico), Puerto Quetzal (Guatemala), San Juan del Sur (Nicaragua), Puntarenas (Costa Rica), Cartagena (Colombia) and Grand Cayman (Cayman Islands).

2019

January 3, 2019: 15-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).

March 4, 2019: 15-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).

March 13, 2019: 16-night Panama Canal cruise on Royal Caribbean. One-way from San Diego to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama) and Cartagena (Colombia).

April 1, 2019: 16-day Panama Canal cruise on Oceania Cruises. One-way from San Diego to Miami (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Havana (Cuba).

April 3, 2019: 15-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).

October 1, 2019: 17-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Aruba, Curacao and Half Moon Cay (Bahamas).

October 3, 2019: 16-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal and Aruba.

November 8, 2019: 14-night Panama Canal cruise on Disney Cruises. One-way from San Diego to Galveston (Texas). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), the Panama Canal, Cartagena (Colombia), Grand Cayman (Cayman Islands) and Cozumel (Mexico). A "Very Merrytime" cruise.

November 16, 2019: 15-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).

November 17, 2019: 16-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Aruba and Half Moon Cay (Bahamas).

2020

February 1, 2020: 13-day Panama Canal cruise on Carnival Cruise Line. One-way from San Diego to Miami (Florida). Visit Huatulco (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, and Cartagena (Colombia).

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