San Diego Cruise Guide
cruise to South America
Machu Picchu

San Diego Cruise Guide > Cruise Destinations > South America

Cruises from San Diego to South America

One cruise line offers cruises from San Diego to Incan and Mayan historic sites in South America and Central America. Choose a round-trip voyage or a one-way cruise to Chile, Argentina or Brazil. See the full schedule of departures below.

Lima (Peru) shore excursions include the Incan wonder of Machu Picchu. The city itself has beautiful historic buildings and excellent restaurants.

Puerto Chiapas (Mexico) is the Pacific gateway to the Mayan world. The port is the starting point for excursions to the ruins at Izapa. Closer to town you can explore a rainforest or shop for local crafts.

From Puerto Quetzal (Guatemala) a flight to Tikal reveals a famous Mayan archaeological site.

The historic quarter of Valparaiso (Chile) is a World Heritage Site. Ride a funicular up to take in views over the city and ocean. About two hours inland is Santiago, the capital of Chile.


35-day cruise to South America on Holland America Line. One-way from San Diego to Rio de Janeiro (Brazil). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Fuerte Amador (Panama), Manta (Ecuador), Salaverry (Peru), Callao (Peru), Coquimbo (Chile), Valparaiso (Chile), Puerto Montt (Chile), Punta Arenas (Chile), Ushuaia (Argentina), Cape Horn, Stanley (Falkland Islands), Montevideo (Uruguay), Buenos Aires (Argentina) and Punta del Este (Uruguay).
• 2018 departure: September 29.


30-day cruise to South America on Holland America Line. Round-trip from San Diego to Cabo San Lucas (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Fuerte Amador (Panama), Manta (Ecuador), Trujillo (Peru), Lima (Peru), Pisco (Peru), Puntarenas (Costa Rica), Corinto (Nicaragua), Puerto Quetzal (Guatemala), Manzanillo (Mexico) and Puerto Vallarta (Mexico).
• 2019 departure: February 2.

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Lima Peru
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