Crystal Cruises offered cruises from San Diego in the past.
Crystal cruise ships win awards for popularity almost every year. These are luxury all-inclusive ships. Features of the Crystal Symphony's recent redesign include the Avenue Saloon piano bar, Bridge Lounge for cards, Galaxy Lounge showroom, Palm Court at the top of the ship for afternoon tea and evening dancing, and Hollywood Theatre.
There are also several Crystal Cruises from Los Angeles. LA isn't far from San Diego.