November 16, 2019: 15-day Thanksgiving cruise through the Panama Canal on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).
November 17, 2019: 16-day Thanksgiving cruise through the Panama Canal on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Aruba and Half Moon Cay (Bahamas).
November 23, 2019: 7-day Thanksgiving cruise to the Mexican Riviera on Holland America Line. Round-trip from San Diego to Cabo San Lucas (Mexico), Mazatlan (Mexico) and Puerto Vallarta (Mexico).
For other options, see the complete calendar of Thanksgiving cruises out of California.