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Panama Canal cruise
Panama Canal cruise ship in lock

San Diego Cruise Guide > Cruise Destinations > Panama Canal

Panama Canal Cruises from San Diego

Three cruise lines offer cruises through the Panama Canal from San Diego. They are one-way trips that end in Florida or Texas. All go fully through the canal, and they visit resort ports along the way. See the schedule of departures below.

This time-lapse video shows a full transit of a cruise ship through the Panama Canal in just 5 minutes. The actual trip was more than 10 hours.

The Panama Canal is 100 years old, and is one of the engineering marvels of the world. A voyage through the canal is a real "must do" adventure. See an interesting 100 years of the Panama Canal in 10 photos gallery by PBS.

Panama Canal cruise itinerary
Panama Canal cruise port of call

2022

January 2, 2022: 14-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal and Cartagena (Colombia).

January 9, 2022: 14-night Panama Canal cruise on Norwegian Cruise Line. One-way from San Diego to Panama City (Panama). Visit Cabo San Lucas (Mexico), Puerto Quetzal (Guatemala), Acajutla (El Salvador), San Juan del Sur (Nicaragua) and Puntarenas (Costa Rica).

January 30, 2022: 14-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal and Cartagena (Colombia).

October 8, 2022: 17-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Aruba and Half Moon Cay (Bahamas).

October 13, 2022: 16-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal and Aruba.

November 17, 2022: 14-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal and Cartagena (Colombia).

2023

January 14, 2023: 12-night Panama Canal cruise on Norwegian Cruise Line. One-way from San Diego to Panama City (Panama). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), San Juan del Sur (Nicaragua) and Puntarenas (Costa Rica).

January 21, 2023: 14-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).

February 18, 2023: 14-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).

April 4, 2023: 14-day Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), the Panama Canal and Cartagena (Colombia).

October 7, 2023: 16-night Panama Canal cruise on Royal Caribbean. One-way from San Diego to Tampa (Florida). Visit Ensenada (Mexico), Cabo San Lucas (Mexico), Huatulco (Mexico), San Juan del Sur (Nicaragua), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).

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