San Diego Cruise Guide > Cruise Destinations > Panama Canal
Three cruise lines offer cruises through the Panama Canal from San Diego. They are one-way trips that end in Florida or Texas. All go fully through the canal, and they visit resort ports along the way. See the schedule of departures below.
This time-lapse video shows a full transit of a cruise ship through the Panama Canal in just 5 minutes. The actual trip was more than 10 hours.
The Panama Canal is 100 years old, and is one of the engineering marvels of the world. A voyage through the canal is a real "must do" adventure. See an interesting 100 years of the Panama Canal in 10 photos gallery by PBS.
January 3, 2025: 15-night Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).
July 3, 2025: 20-night Panama Canal cruise on Oceania. One-way from San Diego to New York (New York). Visit Ensenada (Mexico), Cabo San Lucas (Mexico), Zihuatanejo (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia), Grand Cayman (Cayman Islands), Miami (Florida) and Port Canaveral (Florida).
September 19, 2025: 13-night Panama Canal cruise on Royal Caribbean. One-way from San Diego to Miami (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).
October 4, 2025: 16-night Panama Canal cruise on Royal Caribbean. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Mazatlan (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colong (Panama), Cartagena (Colombia) and Grand Cayman (Cayman Islands).
October 9, 2025: 17-night Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Acajutla (El Salvador), Puntarenas (Costa Rica), the Panama Canal and Aruba.
October 18, 2025: 14-night Panama Canal cruise on Norwegian Cruise Line. One-way from San Diego to Miami (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Panama City (Panama), Cartagena (Colombia) and Grand Cayman (Cayman Islands).
November 1, 2025: 17-night Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Oranjestad (Aruba) and Half Moon Cay (Bahamas).
February 12, 2026: 15-night Panama Canal cruise on Norwegian Cruise Line. One-way from San Diego to Miami (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Panama City (Panama), the Panama Canal and Cartagena (Colombia).
February 27, 2026: 15-night Panama Canal cruise on Holland America Line. One-way from San Diego to Miami (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Fuerte Amador (Panama), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).
May 3, 2026: 14-night Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Puerto Chiapas (Mexico), Acajutla (El Salvador), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
August 24, 2026: 32-night Panama Canal cruise on Crystal. One-way from San Diego to New York (New York). Visit Ensenada (Mexico), Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Acajutla (El Salvador), San Juan Del Sur (Nicaragua), Puntarenas (Costa Rica), Manta (Ecuador), Guayaquil (Ecuador), Fuerte Amador (Panama), the Panama Canal, Cartagena (Colombia), Santo Domingo (Dominian Republic), Punta Canad (Dominican Republic), San Juan (Puerto Rico), Marigot (St Martin), Roseau (Dominica), Bridgetown (Barbados), Castries (St Lucia), St John's (Antigua), Jost Van Dyke (British Virgin Islands), Samana (Dominican Republic) and Grand Turk (Turks & Caicos).
October 2, 2026: 15-night Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Acajutla (El Salvador), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).
October 8, 2026: 16-night Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Cabo San Lucas (Mexico), Acapulco (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal and Aruba.
November 6, 2026: 14-night Panama Canal cruise on Disney Cruise Line. One-way from San Diego to Galveston (Texas). Visit Puerto Vallarta (Mexico), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
December 19, 2026: 15-night Panama Canal cruise on Holland America Line. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).